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differential algorithm acute diseases renal rheumatology injury kidney management neurology pathology pulmonary table ana anca antineutrophil antinuclear associations autoantibodies bloodsmear
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... • Sjögren syndrome ... Vasculitis: • Microscopic ... ANCA+ 90% • Anti-GBM ... #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Microscopic polyangiitis ... U1-RNP antibody ... Celiac disease Anti-GBM ... Associations #diseases #diagnosis ... #rheumatology #antibodies
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
• Hepatorenal syndromes ... Glomerulonephritis • Anti-GBM ... antibodies • ... polyangiitis /microscopic ... #KidneyInjury #Nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... dipstick, urine microscopy ... osmolarity If cause ... Vasculits: ANCA, ANA, Anti-GBM ... #nephrology #causes
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... proliferative • Anti-GBM ... antibodies ... polyangiitis (GPA) / microscopic ... #Proteinuria #Nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... - Differential Diagnosis ... Abdominal Compartment Syndrome ... Vasculitis • GN: ANCA, Anti-GBM ... #nephrology #causes
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... polyangiitis, Microscopic ... ab, anti-GBM ab ... #differential #diagnosis ... #nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
EGPA) • Renal: (AKI ... EGPA) • Auto-antibodies ... : ANCA antibody, ... Anti-GBM antibody ... usually low in anti-GBM
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... glomerular #diseases #nephrology ... comparison #table #diagnosis
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Viruses (HSV, EBV ... ; Positive for anti-ganglioside ... antibody GQ1b) ... #Differential #Diagnosis ... #Causes #Neurology
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