28 results
algorithm vasculitis acute aki classification antibodies antinuclear diseases glomerulonephritis injury kidney management neurology antibody disorders hematology patterns pulmonary renal rpgn
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
of cases) 2 ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
ANCA: • C-ANCA ... Wegener's) • P-ANCA ... Churg Strauss) Anti-GBM ... #diagnosis #nephrology ... #causes
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis) - ANCA-negative ... Disease-specific testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... #diagnosis #nephrology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... - C-ANCA pattern ... 90%, rarely PR3 Anti-GBM ... @AnnKumfer #ANCA ... #Diagnosis #Rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Disease Associations ANA ... Graves' disease c-ANCA ... granulomatosis p-ANCA ... Celiac disease Anti-GBM ... #table #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM ... (C-ANCA): GPA > ... (P-ANCA): eGPA,
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Differential Diagnosis ... Glomerulonephritis / Vasculits: ANCA ... , ANA, Anti-GBM, ... Anti-ds-DNA, C3 ... #Diagnosis #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
cytoplasmic antibody (ANCA ... ) + • c-ANCA: ... staining • p-ANCA ... Classification #Differential ... #Diagnosis #Nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Diagnosis Framework ... Vasculitis • GN: ANCA ... , Anti-GBM, C3/C4 ... #Diagnosis #nephrology ... #causes #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... ): • Microscopic ... often causes arthritis ... glomerulonephritis) • Anti-GBM ... #diagnosis #rheumatology
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