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diagnosis differential management algorithm anca antibodies renal syndrome acute aki antibody antigbm antineutrophil antinuclear associated associations autoantibodies basement canca classification
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... differential #diagnosis #nephrology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
c-ANCA - Vasculitis ... - Vasculitis, e.g ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... diagnosis #table #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Vasculitis: • ... Microscopic polyangiitis ... + 90% • Anti-GBM ... antibodies #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... involvement: Anti-GBM ... Disease (Goodpasture's
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... glomerulonephritis) • Anti-GBM ... (anti-C1q Vasculitis ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... 90%, rarely PR3 Anti-GBM ... disease - MPO>PR3 ... PR3 #Diagnosis #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
vasculitis (AAV ... life-threatening diseases ... antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM ... , Anti-ds-DNA, C3 ... Differential #Diagnosis #nephrology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
)): Microscopic ... often causes arthritis ... GN Anti-GBM (10 ... (anti-C1q Vasculitis ... (anti-C1q Vasculitis
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
A small vessel vasculitis ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology ... #pulmonary
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