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differential rheumatology diseases antibodies causes classification renal table vasculitis algorithm ana anca anti antibody antigbm antineutrophil antinuclear associations autoantibodies basement
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... RPGN • Anti-GBM ... #nephrology #pathology ... comparison #table #diagnosis
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... polyangiitis, Microscopic ... anti-ANCA ab, anti-GBM ... #differential #diagnosis ... #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of glomerular disease ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... staining on IF • No EM ... #Nephrology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... (Diffuse) Anti-Sm ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... #diagnosis #table
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... usually low in anti-GBM
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-Sm (Smith) ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... disease - MPO>PR3 ... Antineutrophil #antibodies #diagnosis
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Viruses (HSV, EBV ... Miller-Fisher GBS ... syndrome - brain stem ... #Differential #Diagnosis ... #Causes #Neurology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
hemorrhage Diagnosis ... : • Anti-GBM antibodies ... weeks By Tess Litchman ... Goodpastures #AntiGBM #diagnosis ... #nephrology #pulmonary
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... progressing GN • New pulmonary ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic
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