19 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
sclerosis • Anti-Glomerular ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
post-infectious GN Anti-Glomerular ... Basement Membrane (GBM ... IF • Majority anti-neutrophil ... + • c-ANCA: anti-proteinase ... Differential #Diagnosis #Nephrology
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Churg Strauss) Anti-GBM ... differential #diagnosis #nephrology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Coxsackie, HIV, CMV, EBV ... Lyme myositis • Rhabdomyolysis ... aminotransferases • Serology ... , anti-La/SSB, anti-Sm ... Differential #Diagnosis #neurology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Infectious: Influenza, EBV ... chemo), EtOH, Rhabdomyolysis ... Diagnosis #causes #neurology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Immune-complex disease, Anti-GBM ... Differential #Diagnosis #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Vasculits: ANCA, ANA, Anti-GBM ... , Anti-ds-DNA, C3 ... cryoglobulins, hepatitis serology ... , HIV serology, ... Differential #Diagnosis #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Vasculitis • GN: ANCA, Anti-GBM ... Differential #Diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... #Proteinuria #Nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
immune deposits on EM ... microangiopathy (TMA), anti-phospholipid ... Glomerulonephritis #MPGN #nephrology