13 results
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
LFTs) - Normal Values ... Indirect bilirubin ... LFTs #Laboratory #Values ... Interpretation #diagnosis ... #hepatology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
- Differential Diagnosis ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin ... #Algorithm #gastroenterology ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... #differential #Diagnosis ... #algorithm #gastroenterology ... #hepatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Defects, Drugs, Liver ... - Unconjugated Bilirubin ... #hematology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... of portal HTN: ascites ... portal HTN: • Ascites ... function: INR, bilirubin ... #causes #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... week • Direct bilirubin ... Elevation: • Bilirubin ... #chemistry #diagnosis ... #differential #Hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
develops (DIC, ascites ... Antithrombin Ill • Ultrasound ... ) Differential Diagnosis ... #Pregnancy #hepatology ... obstetrics #obgyn #diagnosis
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... >1.5, and both values ... • Serum total bilirubin ... ) or metabolic liver ... Hepatitis #AH #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... - Serum total bilirubin ... ) or metabolic liver ... #Hepatology #AIH
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
of hemolysis or liver ... birth with serum bilirubin ... associated with bilirubin ... #hepatology #diagnosis ... #gastroenterology