41 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
• R value = (ALT ... + ULN ALT) / (alkaline ... phosphatase + ULN alkaline ... Transaminitis #diagnosis #differential ... #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... Most common symptoms ... disease - Bone symptoms
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
LFTs) - Normal Values ... Interpretation Alanine ... , lungs, RBCs Alkaline ... LFTs #Laboratory #Values ... Interpretation #diagnosis #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... Transaminase >> Alkaline ... Cholestatic Pattern - Alkaline ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... compared with alkaline ... disproportionate increase in alkaline ... Injury Differential ... #Diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... infiltration) Differential ... Monitor and Treat Complications ... #Pregnancy #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... Tests - AST, ALT, Alkaline ... Alkaline phosphatase ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Complications of Measles: Pathogenesis and Clinical Findings
 • ADEM -> Fever, headache, neck stiffness, BBD, mental
Complications of ... N/V, elevated liver ... infections #Measles #Complications ... diagnosis #signs #symptoms ... #pathophysiology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Pancreatitis - Elevated Liver ... Gastrointestinal #Complications ... #pathophysiology ... #signs #symptoms
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
ongoing ↑ LFTs or symptoms ... of liver disease ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology