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differential liver algorithm transaminitis causes management acute classification dili elevation function gastroenterology interpretation laboratory lactate tests abnormal acidosis aclf ah
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... AST:ALT > 2.5 - Alcoholic ... Patterns #Liver #Injury ... #hepatology #LFTs ... #differential #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
→ liver test abnormalities ... Drugs (MDMA), Alcohol ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Liver Function Tests ... (LFTs) - Differential ... Diagnosis Framework ... Drug-induced liver injury ... #Diagnosis #hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
of Alcoholic Hepatitis ... >1.5, and both values ... atypical laboratory tests ... #diagnosis #Alcoholic ... #hepatology #criteria
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential Diagnosis ... HSV • Toxic: Alcohol ... #Differential #Diagnosis ... Acute #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
- Differential Diagnosis ... • Cholestatic disease ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... atypical laboratory tests ... #Diagnosis #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... ALT Ratios: • Alcoholic ... liver #chemistry #diagnosis ... #differential #Hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... symptoms of liver disease ... Calculate R-Value ... gastroenterology #hepatology
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