19 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
- Differential Diagnosis ... (48-70%) Cold ... Agglutinin Disease ... #Differential #Diagnosis ... #Table #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
air, objects, liquids ... fatigue, Nausea, abdominal ... Disorientation, vertigo Diagnostic ... #Urticaria #diagnosis ... #rheumatology #
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... , Cold AIHA, Transfusion ... Laboratory Tests ... #hematology
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
, C3d ( +/- ) Cold ... agglutinin disease ... #antiglobulin #test ... Autoimmune #Hemolysis #hematology ... #diagnosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential Diagnosis ... • Cold AIHA ... Prosthetic heart valves ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... atypical laboratory tests ... #Diagnosis #Hepatology ... #AIH
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... >1.5, and both values ... atypical laboratory tests ... #Hepatitis #AH ... #hepatology #criteria
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
women • 15% of AIHA ... Test: Donath-Landsteiner ... test #cold # ... hemolytic #anemia #hematology ... #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... - Autoimmune (AIHA ... )"Cold" (usually ... (e.g. primary cold ... #hematology #anemia
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
in those with CLD ... underlying liver disease ... (AAH) Drug-Induced ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis