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hematology differential workup anemia algorithm causes hemolysis hemolytic management autoimmune comparison platelet syndrome table testing agglutinin aggregometry ah aih alcoholic
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
fatigue, Nausea, abdominal ... Disorientation, vertigo Diagnostic ... test, TempTest ... #Urticaria #diagnosis ... #rheumatology #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... Test: Donath-Landsteiner ... test #cold # ... hemolytic #anemia #hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
, C3d ( +/- ) Cold ... agglutinin disease ... #antiglobulin #test ... Autoimmune #Hemolysis #hematology ... #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Autoimmune: Warm AIHA, Cold ... Laboratory Tests ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... practices that could ... K), H. pylori test ... thyroid function test ... Causes #Workup #hematology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... >1.5, and both values ... atypical laboratory tests ... #diagnosis #Alcoholic ... #hepatology #criteria
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Advanced Liver Disease ... Alcohol, Viral hepatitis ... Malignancy, Autoimmune disorders ... table #comparison #diagnosis ... #hematology #deficiency
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... atypical laboratory tests ... #Diagnosis #Hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... lymphoproliferative disorders ... #hematology #anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... Cell Agglutinate: Cold ... anemia, Paroxysmal cold ... #differential #diagnosis ... #hematology #microscopy
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