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differential algorithm transaminitis causes injury classification clinical elevation function hematology interpretation laboratory management obgyn obstetrics pregnancy rheumatology tests workup 1
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Chronic Viral Hepatitis ... #Function #Tests ... #Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
test abnormalities ... • Infections: Hepatitis ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... Values and Interpretation ... #Function #Tests ... #diagnosis #hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... >1.5, and both values ... ) or metabolic liver ... atypical laboratory tests ... #hepatology #criteria
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... ) or metabolic liver ... atypical laboratory tests ... #Diagnosis #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... disease: > 2 ... #chemistry #diagnosis ... #differential #Hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
disease; AST, aspartate ... disease; T2DM, ... mellitus; USS, ultrasound ... #LFTs #Abnormal ... #Algorithm #Hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... gastroenterology #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
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