33 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Calculate R-Value ... #DILI #Drug #induced ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... Differential Diagnosis ... • DILI (Drug-induced ... #Function #Tests ... #hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Hepatitis (AAH) Drug-Induced ... Hepatitis Procedures Management ... Failure #Cirrhosis #Hepatology ... gastroenterology #management ... #diagnosis
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... LFTs) - Normal Values ... #Function #Tests ... Interpretation #diagnosis ... #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Tests - AST, ALT ... synthesis, not reduced ... #Chemistry #Tests ... AlkPhos #Bilirubin #Hepatology ... Pathophysiology #Diagnosis
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... >1.5, and both values ... Possible drug-induced ... liver disease ( ... atypical laboratory tests
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... Possible drug-induced ... atypical laboratory tests ... #Hepatology #AIH
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... Second-line tests ... children, the text ... algorithm #Referral #Management ... #Hepatology
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
Test for the respective ... Liver biopsy • ... biopsy • Lab values ... supporting hematologic ... UnknownOrigin #workup #diagnosis