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hematology management oncology infectiousdiseases parasite chronic differential hemeonc hemophagocytic hlh leukemia lymphocytic lymphohistiocytosis workup algorithm american apml bandemia cbc classification
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
incompetent • CLL ... Diagnosis: • ... microglobulin Treatment ... Lymphocytic #Leukemia #diagnosis ... workup #oncology #hematology
Leishmaniasis Life Cycle 1) Sandfly takes a blood meal (injects promastigote stage into the skin) Human Stages: 2) Promastigotes
and infect other cells ... of parasitized cell ... Leishmaniasis #LifeCycle ... #diagnosis #pathophysiology ... infectiousdiseases #cdc
Malaria - Plasmodium Life Cycle 1) Mosquito takes a blood meal (injects sporozoites) Human Liver Stages 2) Infected liver
Infected liver cell ... Malaria #Plasmodium #lifecycle ... #diagnosis #pathophysiology ... infectiousdiseases #cdc
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... minimal tumor burden Diagnosis ... Transformation to large cell ... uw_IMresidency #CLL ... #hemeonc #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... common - T Cell ... ~10% - B-Cell ... Classification #pathophysiology ... #Hematology #Diagnosis
Trypanosomiasis - Trypanosoma cruzi Life Cycle 1) Triatomine bug takes a blood meal (passes metacyclic trypomastigotes in
Inside cells they ... burst out of the cell ... TrypanosomaCruzi #Tcruzi #LifeCycle ... #diagnosis #pathophysiology ... infectiousdiseases #cdc
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... ++: Hodgkin, T-cell ... lymphoma, B-cell ... #management #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Release from blast cells ... • Induce blast cell ... Renal Failure Treatment
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • Cell ... precursors" • Stab cell ... Differential Diagnosis ... neutrophil #WBC #CBC ... #hematology #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Pathophysiology ... and CD8+ T cells ... Low/absent NK-cell ... Hematopoietic stem cell ... #Management #Hematology
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