15 results
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... Diagnosis: • Pancytopenia ... to MDS or acute leukemia ... #Anemia #diagnosis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... (EBV) • Leukemia ... #Anemia #oncology ... #hematology #diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
- Differential Diagnosis ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Leukemia, Tumour ... #Hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
deficiency • Fanconi’s anemia ... telomeropathy Cancer ... : • Leukemia • ... • Epstein-Barr virus ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... • Marrow Aplasia ... Inflammation • Cancer ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... Algorithm Features ... hepatomegaly • Labs: anemia ... #Algorithm #hematology ... #WBC #Leukemoid
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
- Summary Cancer ... with no early symptoms ... • Neutropenia, anemia ... Pure red cell aplasia ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
minimal tumor burden Diagnosis ... of anemia or thrombocytopenia ... marrow failure with anemia ... #oncology #hematology ... #hemeonc #diagnosis