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diagnosis hematology causes hemolytic classification microcytic workup aiha anemias aplastic approach autoimmune calculation elevatedmcv extravascular index intravascular macrocytic macrocytosis management
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... bilirubin • ↑ Reticulocytes ... Hypersplenism, Infection ... #Anemias #Differential ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... Macroangiopathic, Infections ... #MCV #Algorithm ... Diagnosis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... , MCV, MCH, MCHC ... #Diagnosis #Algorithm ... #Causes #Hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... (cell) volume (MCV ... acute blood loss, hemolysis ... #Workup #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
) - Differential ... Diagnosis Algorithm ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
(e.g. cancer, infection ... Microangiopathic hemolytic ... G6PD deficiency), Infections ... Production #Index #hematology ... #anemia #differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Corpuscular Volume (MCV ... ) - Differential ... Diagnosis Algorithm ... #Differential # ... #Causes #Hematology
General Approach to Anemia - Differential Diagnosis Framework 1) Check reticulocyte count to determine if hypo/hyper-proliferative 2) Exclude
- Differential ... hyper-proliferative 2) Exclude hemolysis ... haptoglobin) 3) Use MCV ... diagnosis #hematology ... #algorithm #reticulocyte
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... circulation - Infections ... anemia • ... #Causes #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
) - Differential ... Diagnosis Algorithm ... +/- increased reticulocytes ... #Diagnosis #Algorithm ... #Causes #Hematology
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