19 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Elevated Platelet ... → Refer to hematology ... Vasculitides, IBD, Celiac disease ... #Platelets #Differential ... #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
- Differential ... Diagnosis Algorithm ... Thrombocytopenia ... Sequestration Disordered Platelet ... #Causes #Hematology
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Thrombocytopenia ... - Differential ... Diagnosis Algorithm ... #Differential # ... #hematology #platelets
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Diagnosis Algorithm ... Symptoms: B-symptoms, bruising ... anemia, ↑ MCV, ↑/↓ platelets ... #hematology #WBC
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
1 or Type 3) — differentiate ... Gplb receptor • Thrombcytopenia ... Von Willebrand Disease ... #disorders #hematology ... #hemepath #differential
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... Clinical • Easy bruising ... Laboratory • Normal platelet ... count (mild thrombocytopenia ... #Diagnosis #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential ... Diagnosis Algorithm ... disorders • Celiac disease ... following EtOH induced thrombocytopenia ... #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
RBC's secondary to platelet ... • Platelet defects ... NON-PALPABLE PURPURA: Platelet ... #Diagnosis #hematology ... #rheumatology #
Platelet Disorders - Differential Diagnosis Framework

Qualitative Defects:
 • Adhesion
 • Aggregation
 • Secretion

Quantitative Defects:
 • Production:
Platelet Disorders ... - Differential ... ASanchez_PS #Platelet ... #Diagnosis #hematology ... #thrombocytopenia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... - Differential ... History: - Prior platelet ... #Platelet #Disorders ... Causes #Workup #hematology