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diagnosis differential algorithm hematology causes management clinical workup pathophysiology nephrology symptoms signs treatment hepatology syndrome microscopy neurology hemolytic pocus cardiology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
hepatomegaly • Labs: anemia ... platelets, persistent WBC ... Algorithm #hematology #WBC
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Pelger-Huet, Macrocytic anemia ... bcr-able (+) ↑ WBC
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Albumin ≤3.0 g/dL, anemia ... ≥450,000/mm3, WBC ... and urine ≥10 WBC
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... immune hemolytic anemia ... from ischemia WBC
Toxic Megacolon Inflammatory bowel disease or Infectious colitis characterized by total or segmental nonobstructive colonic dilatation
• HR > 120 • WBC ... > 10.5 • Anemia
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Algorithm Decreased WBCs ... Normal/lncreased WBCs ... Microangiopathic Hemolytic Anemias ... #Normocytic #Anemia
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... • Extrinsic RBC ... • Intrinsic RBC ... #Hemolytic #Anemias
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chronic disease anemia ... Sideroblastic anemia ... Microangiopathic Hemolytic Anemia ... autoimmune hemolytic anemia
Urine Microscopy and Casts - Image Atlas Key - Squamous Epithelial Casts - Transitional Epithelial Cells - Renal Tubular
Hyaline Cast - WBCs ... Granular Casts - WBC ... Cast - RBC Cast
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