14 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Diagnosis Algorithm ... #Anemias #Differential ... #Diagnosis #Algorithm ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Diagnosis Algorithm ... Decreased WBCs ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... Diagnosis #Algorithm
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... Anemia 1) DIAGNOSE ... reticulocytes • Hemolysis ... Antibody #Autoimmune #Hemolytic ... #Anemia #diagnosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... Diagnosis Algorithm ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... #Diagnosis #Algorithm
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... #diagnosis #hematology ... #microscopy #atlas
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... intravascular hemolysis ... agglutinin #disease #hemolytic ... #anemia #hematology
General Approach to Anemia - Differential Diagnosis Framework
1) Check reticulocyte count to determine if hypo/hyper-proliferative
2) Exclude
- Differential ... hyper-proliferative 2) Exclude hemolysis ... ) 3) Use MCV & clinical ... diagnosis #hematology ... #algorithm #reticulocyte
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
immunophenotype Clinical ... 5) Symptoms of anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management