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differential causes pruritus rheumatology classification cll dermatology generalized leukemia lymphocytic secondary thrombocytosis workup abscess antibody aplastic approach arthritis atlas bacilliformis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... , Chronic disease ... ): Artifact, Uremia ... #differential #diagnosis ... #hematology #microscopy
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... • Anemia: macrocytic ... #Hemolytic #Anemia ... #diagnosis #management ... #treatment #rheumatology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Algorithm Blood ... • Anemia of Chronic ... Non-lmmune #Anemia ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Algorithm Spurious ... Artifact (redo CBC ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... kidney disease, ... • Hemolysis: Autoimmune ... Production #Index #hematology ... #diagnosis #calculation
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... == Blood Glucose ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Hyperthyroidism CBC
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... chemotherapy for low-risk disease ... marrow failure with anemia ... #hematology #hemeonc ... #diagnosis #management
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Algorithm Blood ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Hyperthyroidism CBC ... Pruritus #secondary #systemic
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
: Acute blood loss ... hemolysis, deficiency anemia ... Rebound effect from treatment ... • Infections: Chronic ... #Algorithm #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... Treatment: ... result from low blood ... #oncology #hematology ... #diagnosis #management
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