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differential management hematology causes oncology algorithm renal workup aki barre cancer classification disease encephalopathy erythematosus guillain infectiousdiseases interpretation lupus peripheral
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... Malignant tumors, Acute ... PD deficiency, Pulmonary ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... transformation to acute ... #Management #treatment ... #hematology #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Artifact (redo CBC ... Infectious: • Acute ... effect following treatment ... Iron deficiency anemia
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... if high risk if WBC ... Imaging: CXR- pulmonary ... QD until normal WBC
Korsakoff Syndrome Clinical Findings: • Confabulation: Usually initial phase of the disease • Anterograde amnesia: Memory impairment
Korsakoff Syndrome ... • Anterograde amnesia ... Therefore, Korsakoff Syndrome ... Encephalopathy Treatment ... #neurology #diagnosis
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Differential Diagnosis ... Investigations • Labs: CBC ... #differential #diagnosis ... #nephrology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... Treatment: ... #oncology #hematology ... #diagnosis #management
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
important, as early diagnosis ... and treatment can ... • Acute disseminated ... #neurology #inflammatory ... #differential #diagnosis
Urine Microscopy - Casts Acellular Casts • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
suggestive of acute ... in a variety of acute ... glomerulonephritis • WBC ... Urine #Microscopy #nephrology ... interpretation #diagnosis
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