16 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Hemolysis - Differential ... elliptocytosis - RBC ... PK deficiency Intravascular ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - Intravascular ... • Intrinsic RBC ... Hemolysis #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Approach to Anemia - Differential ... RBCs Decreased RBC ... Non-lmmune #Anemia #Classification ... #Approach #Differential ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... IVIG infusion Intravascular ... Hemolytic #Anemia #Differential ... Diagnosis #causes #classification ... #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... , Disseminated intravascular ... coagulopathy (DIC) #RBC ... key #diagnosis #differential ... #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Microangiopathy (TMA) - Differential ... Diagnosis and Management ... Initial labs: CBC ... #Diagnosis #Management ... #Algorithm #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
↑ LDH • Anti-RBC ... • Blood smear: Differential ... Anemia #diagnosis #management ... #treatment #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... hydration • RBC ... #Disseminated #Intravascular ... causes #treatment #management ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
reflection of intravascular ... from ischemia WBC ... count and differential ... Diagnosis #Workup #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
if high risk if WBC ... initiation • Differential ... QD until normal WBC ... APML #diagnosis #management ... #hematology #oncology