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rheumatology differential hepatology oncology dermatology algorithm neurology biliary causes sclerosis summary workup anemia antibodies autoimmune cholangitis chronic classification cll dress
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
biliary cirrhosis ... (PBC), or with ... systemic diseases ... #Pathophysiology ... #Diagnosis #Signs
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Cirrhosis - Diagnosis ... quadrant discomfort Signs ... PBC if 2/3 criteria ... consistent with PBC ... #PBC #Primary
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... Pathophysiology ... Signs and Symptoms ... #hepatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... and Symptoms: ... pericarditis • Hepatic: PBC ... (primary biliary ... #diagnosis #signs
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... Psychiatric Disease ... #generalized #dermatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
, Anti-gp210 - Primary ... biliary cirrhosis ... (PBC) Anticentromere ... #diagnosis #table ... #rheumatology #
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Treatment Stop offending agents: • List as allergies
Symptoms (DRESS ... ) Syndrome Treatment ... monitoring: • CBC ... #Treatment #Management ... #dermatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Pathophysiology ... if high risk if WBC ... : >3 symptoms, or ... QD until normal WBC ... #management #hematology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
The 6 C’s of Primary ... asymptomatic at diagnosis ... Care focuses on symptom ... management. ... #Hepatology
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