27 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
biliary cirrhosis ... (PBC), or with ... systemic diseases ... #Pathophysiology ... #Diagnosis #Signs
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Cirrhosis - Diagnosis ... quadrant discomfort Signs ... PBC if 2/3 criteria ... consistent with PBC ... #PBC #Primary
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Cirrhosis (PBC) ... - Summary PBC ... Pathophysiology ... Signs and Symptoms ... #hepatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
autoimmune disease ... and Symptoms: ... pericarditis • Hepatic: PBC ... (primary biliary ... #diagnosis #signs
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Pathophysiology ... if high risk if WBC ... : >3 symptoms, or ... QD until normal WBC ... #management #hematology
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
and Management ... incidentally via CBC ... , signs, and complications ... von Willebrand disease ... #treatment #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... , PRES Pathophysiology ... Erythematosus #SLE #CNS #neurology ... #management #treatment
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Episcleritis Signs ... - CBC may also ... Treatment: - Systemic ... #diagnosis #dermatology
Primary Biliary Cirrhosis - Management
A. Initiate therapy 
 - Initiate 1st line therapy with UDCA (13-15
Cirrhosis - Management ... Manage symptoms ... Stage & survey disease ... #PBC #Primary ... #Management #Treatment