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diagnosis causes algorithm management nephrology hematology neurology cardiology rheumatology table hepatology workup dermatology pulmonary clinical endocrinology gastroenterology pediatrics comparison oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... if high risk if WBC ... initiation • Differential ... QD until normal WBC
Algorithm and Differential Diagnosis of Macroscopic Hematuria Important Historical Elements: - Painless: suggests malignancy - Painful: suggests calculi/infection - Urinalysis:
Algorithm and Differential ... dysmorphic RBC’s, RBC ... /WBC casts, proteinuria ... #Macroscopic #Differential
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria - Differential ... • Fanconi's syndrome ... urine sediment - WBC ... /RBC casts ... Proteinuria #Nephrology #Differential
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... glomerular hematuria (RBC ... Nephritic #Nephrotic #Syndrome
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Lymphadenopathy - Differential ... (Pancytopenia, WBC ... differential includes ... Lymphocytic Leukemia (CBC ... Lymphadenopathy #LAD #Differential
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... platelets, persistent WBC ... #Leukocytosis #Differential ... Algorithm #hematology #WBC
Hyperthermia Syndromes Comparison Serotonin Syndrome - NMS - Malignant Hyperthermia - Malignant Catatonia Cause - Onset - Vitals
Hyperthermia Syndromes ... Comparison Serotonin Syndrome ... Mental Status - Treatment ... #Hyperthermia #Syndromes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Algorithm Decreased WBCs ... Normal/lncreased WBCs ... Spherocytes, RBC ... Normocytic #Anemia #Differential
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... Nephrotic yndrome—podocyte ... Nephritic #Nephrotic #Syndromes
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