34 results
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)
SLE patient develops
Lupus Nephritis ... approach to kidney disease ... with systemic lupus ... casts, WBC casts ... Non-LN Kidney Disease
Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Lupusreference #Renal #diseases ... #SLE #Systemic ... #Lupus #Erythematosus ... venn #nephrology #nephritis ... classification #types #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
nephritis, NPSLE ... • Immunologic Workup ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC ... Erythematosus #Diagnosis #Rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Arthritis R Renal Disease ... (Nephritis) P ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... nephritis, NPSLE ... • Immunologic Workup ... Evolution: Chronic disease ... #table #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... Farr assay) and lupus ... nephritis. ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... • Specific for SLE ... Treatment: • ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Hemolytic anemia ... involvement 3% SLE-Related ... sclerosis, Still's disease ... Lupusreference #SLE ... #differential #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... ): SS, SC, SE, Sβ ... ARUPLabs #Hemolytic #Anemia ... Diagnosis #Algorithm #workup ... #hematology #testing