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diagnosis hematology algorithm bloodsmear causes management microscopy rbc oncology treatment atlas autoagglutination classification fever laboratory macrocytic macrocytosis morphology pathophysiology peripheral
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... AIHA • Anemia ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... smear + DAT + further ... malignancy, autoimmune disease ... #Anemia #Differential
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Smear Analysis ... cells: Sickle cell disease ... #Smear #Analysis ... interpretation #clinical
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... , McLeod blood group ... Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... #Morphology #differential
Dacrocytes (tear drop cells) Other poikilocytes resemble a pear or teardrop. The narrow, tapered end may be
thalassemia, and some hemolytic ... anemias. ... #Clinical #Path ... #BloodSmear #Blood ... #Smear #Dacrocytes
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm Blood ... Normochromic RBCs on Smear ... Disease • Marrow ... Spherocytes on Smear
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... - Peripheral Blood ... Smear ↑ abnormal ... #Differential #
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... key #diagnosis #differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
turnover • Acute blood ... loss • Hemolytic ... anemia • Splenomegaly ... End-stage renal disease ... Diagnosis #DM2 #Differential
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