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diagnosis hematology algorithm management oncology treatment atlas bloodsmear classification fever macrocytosis morphology pulmonary rbc syndromes aafp abscess agglutinin antibody approach
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
: macrocytic > normocytic ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential ... 2) LOOK FOR a cause
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... smear + DAT + further ... malignancy, autoimmune disease ... #Anemia #Differential
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Microcytic RBC: ... (sometimes) Macrocytic ... , McLeod blood group ... #Morphology #differential
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal Blood ... Smear • Drugs ... Oval Macrocytes ... Cells, Normal WBCs
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Lead poisoning • Macrocytic ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... key #diagnosis #differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... deficiency • Asplenia ... turnover • Acute blood ... loss • Hemolytic ... End-stage renal disease
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... (RBC = red blood ... ordering a peripheral smear ... Hemorrhage or hemolysis ... the most likely cause
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm Blood ... Normochromic RBCs on Smear ... Disease • Marrow ... Diagnosis #Algorithm #Causes
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... plateletcount), peripheral blood ... smear, HIV/HCV ... changes), high MCV anemia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... - Peripheral Blood ... Smear ↑ abnormal ... #Differential #
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