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Whipple Disease (Tropheryma whipplei) - Diagnostic Algorithm

Whipple's disease suspected:
 • Arthralgias, weight loss, abdominal pain, diarrhea
Whipple Disease ... (Tropheryma whipplei ... Diagnostic Algorithm Whipple's ... unknown origin, chronic ... MatthewHoMD #Whipple
Chronic Diarrhea - Differential Diagnosis Algorithm
Steatorrhea
 - Maldigestive
    • Pancreatic Insufficiency
 - Primary
Chronic Diarrhea ... with TTG) • Chronic ... Inflammation • Whipple's ... • Lymphoma #Chronic
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
acute/subacute/chronic ... Caused By: - Chronic ... Gout/Pseudogout Chronic ... • Tropheryma whippleii ... (Whipple's disease
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm
Neoplasm:
• NHL
• Hodgkin's lymphoma
• Leukemia
• Solid
Lyme disease • Whipple's ... UnknownOrigin #FUO #Chronic
Causes of Severe Aortic Regurgitation - Differential Diagnosis
Acute:
 • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Injury to Root Chronic ... Rheumatic Fever, Whipple ... Valve Dysfunction Chronic
Causes of Fat Malabsorption - Differential Diagnosis
Biliary Duct Obstruction
 • Autoimmune— PBC, PSC
 • Infection— liver
- Acquired • Chronic ... Giardiasis • Whipple
Pancreatic Exocrine Insufficiency (PEI) - Diagnostic Algorithm
PEI definite:
 • Total pancreatectomy
 • Severe chronic pancreatitis
 •
pancreatectomy • Severe chronic ... Mild and moderate chronic ... pancreatitis • After Whipple
Causes of mitral stenosis
Rheumatic heart disease
 - Most common cause worldwide. Commissural fusion, thick MV leaflets
Age-related changes, chronic ... endomyocardial fibrosis, Whipple's
Whipple Disease (Tropheryma whipplei) - Diagnosis and Management 

Caused by: Tropheryma whipplei

Symptoms and Signs:
1. Migratory poly/oligoarthralgia
Whipple Disease ... (Tropheryma whipplei ... by: Tropheryma whipplei ... One positive T. whipplei ... MatthewHoMD #Whipple
Causes of Chronic Diarrhea
Osmotic Diarrhea
 1. Medications: antacids, lactulose, sorbitol
 2. Disaccharidase deficiency: lactose intolerance
 3.
Causes of Chronic ... tropical sprue, Whipple ... Pancreatic disease: chronic ... bowel syndrome Chronic ... Factitious #Chronic