13 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... virus (EBV) • Leukemia ... #Anemia #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... #oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Age > 50 • Chronic ... #Causes #Hematology ... #Oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... • Marrow Aplasia ... RA, SLE, PRV, Chronic ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... RBCs on Smear • Chronic ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia ... : • Acute or Chronic ... Iron deficiency anemia ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Myelodysplastic syndrome ... myeloid leukemia ... #hematology #secondary
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... Pure red cell aplasia ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... -> AML: Blast crises ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Hematology #Oncology