22 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... #differential # ... diagnosis #algorithm ... #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Diagnosis Framework ... Urticarial/LCV) - Cryoglobulinemic ... polyangiitis - EGPA ... #dermatology #rheumatology ... diagnosis
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
vasculitis - Diagnosis ... , causes and management ... - French Vasculitis ... #Vasculitis #Rheumatology ... #Diagnosis #Management
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
vasculitis Associated ... min/1.73 m2 at diagnosis ... • Dialysis at diagnosis ... #Vasculitis #Management ... #Rheumatology #
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
(5%): PAN > GPA ... , EGPA • Solid ... hemopathies (4%) • Cryoglobulinemia ... signs #lesions #diagnosis ... pathology #lesions #differential
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated Vasculitis ... polyangiitis (eGPA ... #differential # ... diagnosis #algorithm ... #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Labs/Diagnosis: ... - GPA, EGPA, microscopic ... Cryoglobulins #diagnosis ... classification #rheumatology ... #vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... capillaritis • EGPA ... ANCA +MPO) • Cryoglobulinemic ... differential #diagnosis ... #rheumatology #
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... /HSP • Cryoglobulinemia ... - GPA - EGPA ... #Diagnosis #hematology ... #rheumatology #
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
Diagnosis Framework ... Kaposi's sarcoma • Rheumatologic ... Autoimmune: ANCA-Assoc vasculitis ... (GPA > EGPA, MPA ... ), Cryoglobulinemia