17 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
distal to elbows/wrists ... : scleroderma renal ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... TerrierBen #Renal ... Cryoglobulinemia #Vasculitis #Management ... #Rheumatology # ... Cryoglobulinemic #Nephrology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
severe disease & renal ... block • Sjogren syndrome ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... Neurologic-Centered ... capillary leak syndrome ... Cryoglobulinemia Renal-centered ... #hematology #oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Erythematosus #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis ... #management #treatment
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
pancreas, biliary, renal ... PET-CT Imaging (→ Diagnostic ... #management #phenotypes ... #workup #treatment ... #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Anaphylaxis, Acute Renal ... Differentiation #Syndrome ... #APML #diagnosis ... #management #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
capillary leak syndrome ... et diutinum Neurologic ... vascular beds-renal ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
skin injury) • Neurologic ... artery aneurysms Diagnosis ... ) Differential Diagnosis ... #diagnosis #management ... signs #symptoms #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... phenomenon (16%) MSK ... #Rheumatology # ... Diagnosis #Management