12 results
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
- Differential Diagnosis ... Algorithm Infectious ... Inflammatory • Systemic Lupus ... #Algorithm #Causes ... #Hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... Positive in 60-80% of cases ... Evolution: Chronic disease ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... permeability Diagnosis ... (for secondary APS ... CNS #neurology #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
especially in the wrists ... many differential diagnoses ... search ANA and aPL ... #diagnosis #sle ... erythematosus #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... • Malar rash - spares ... Erythematosus #Diagnosis ... #Rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... involvement: Anti-GBM Disease ... #differential #diagnosis ... #algorithm #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Autoimmune Vasculitis (lupus ... Rash: - ITP - APLS ... deficiency Work ... #Algorithm #Causes
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Algorithm Polycythemia ... you’ll do a good workup ... can drive this disease ... As with many disease ... #Algorithm #workup
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
Hypercoagulable Workup ... maternal chromosomal causes ... excluded Testing: • Lupus ... #Algorithm #diagnosis ... #hematology