9 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
HELLP Syndrome and Acute ... Fatty Liver of ... Hemolysis, Elevated Liver ... #HELLP #AFLP #obstetrics ... #hematology #diagnosis
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Hemolysis, Elevated Liver ... exchange 2) Fatty liver ... #HELLP #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... : • Defect in fetal ... #Pregnancy #hepatology ... #obstetrics #obgyn
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Pregnancy Intrahepatic ... Cholestasis of Pregnancy ... and hemorrhage Acute ... #hepatology #obstetrics ... #differential #diagnosis
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
) • Advanced Liver ... Septic shock, Obstetric ... catastrophes, Acute ... table #comparison #diagnosis ... #hematology #deficiency
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
Diagnostic Criteria ... inflammatory disease, or pregnancy ... Excellent response to treatment ... rate >20 mm/h; positive ... #Hematology #Dermatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
: 33% • Treatment ... At least 3 of (Acute ... heart failure, positive ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
presents as an acute ... lymph node, or liver ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
malignancy (Especially acute ... DIC • Severe Liver ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology