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diagnosis hematology algorithm causes aflp classification deficiency disease lactate liver management obstetrics pathophysiology reticulocyte thrombocytosis acidosis agglutinin analysis atlas blood
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... Normal RBCs • Acute ... Hypothyroid • Pregnancy ... #Normocytic #Anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... anemia • ... Acute HTR - Mechanical ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Megaloblastic Anemia ... anemia (e.g. ... anemia Sickled ... interpretation #clinical ... #anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
spherocytosis, Hemolytic ... Malignant tumors, Acute ... Schistocytes - Hemolytic ... key #diagnosis #differential ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... Index > 3: • Acute ... anemia, Intrinsic ... #anemia #differential
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... - Differential ... extravascular) hemolysis ... intake: Anorexia, Pregnancy ... Iron #Deficiency #Anemia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects: Sickle cell anemia ... #Differential # ... Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... Thrombocytosis): • Acute ... malignancies • Anemia ... iron deficiency, hemolysis ... Diagnosis #Causes #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... anemia, PNH, immune ... - Pernicious anemia ... - Prosthetic valves ... hepatitis • Acute
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... result in severe anemia ... anemia Indirect ... WBC count and differential
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