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differential hematology management syndrome antiphospholipid endocarditis marantic nbte noninfective obstetrics workup aflp algorithm anesthesia anesthesiology anticoagulation apls arterial aspirin bandemia
Low-dose aspirin and low-molecular-weight heparin in lupus and Antiphospholipid Syndrome (APS) pregnancy • No previous history of
) pregnancy • ... previous history of thrombosis ... or pregnancy complications ... Previous history thrombotic ... of gestation OR fetal
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... Intravenous Drug Use • Pregnancy ... from prosthetic valves ... Infected cardiac valves ... Venous #Arterial #pathophysiology
Oxyhemoglobin Dissociation Curve Left Shift - decreased unloading of O2 at tissue level (i.e. increased
variant • fetal ... diphosphoglycerate: • pregnancy ... Dissociation #Curve #Pathophysiology ... Differential #Causes #Diagnosis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Fatty Liver of Pregnancy ... (AFLP) Pathophysiology ... : • Defect in fetal ... , ↑Tbili/Dbili/AP ... ) Differential Diagnosis
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Thrombotic Microangiopathy ... (catastrophic APS ... transplant, infection, pregnancy ... @AnnKumfer #Thrombotic ... TMAs #hematology #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... priapism • Lab values ... Lysis Syndrome: • Pathophysiology ... sudden death • Lab values ... Syndrome #TLS #diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... vasculopathy, thrombosis ... permeability Diagnosis ... (for secondary APS ... rheumatology #cerebritis #diagnosis
Non-Infective Endocarditis (NBTE / Marantic Endocarditis) Non-infective endocarditis is also known as: Non-bacterial thrombotic endocarditis (NBTE), Aseptic
is also known as ... Non-bacterial thrombotic ... left-sided heart valves ... is required for diagnosis ... #pathophysiology
13 Dangerous Causes of Headache: - subarachnoid hemorrhage: family history, PCKD, known berry aneurysm, sudden and
cerebral venous sinus thrombosis ... preeclampsia: late pregnancy ... postpartum #Diagnosis ... Killers #Lethal #Fatal
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
specific to NBTE, and diagnosis ... is required for diagnosis ... Non-Bacterial Thrombotic ... Autoimmune (SLE/APLS ... left-sided heart valves
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