18 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Microangiopathy - TTP VS HUS ... Often hard to differentiate ... HUGE treatment ... #Comparison #Diagnosis ... #Table #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
- Differential ... Diagnosis Algorithm ... Autoimmune • ITP • SLE ... Syndrome • TTP/HUS ... #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
- Differential ... Diagnosis Framework ... Microangiopathy: DIC, TTP, HUS ... - Autoimmune: SLE ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... : • DIC, TTP/HUS ... #Diagnosis #hematology ... #rheumatology #
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
triad of MAHA + thrombocytopenia ... catastrophic APS, SRC, SLE ... Microangiopathy #TMAs #hematology ... #diagnosis #ttp ... #hus
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Neurological 12% - Thrombocytopenia ... involvement 3% SLE-Related ... ) 30-45% Differential ... Lupusreference #SLE ... #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... test, ANA (e.g., SLE ... not required in all ... #Workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... genotypes): SS, SC, SE ... Schistocytes, thrombocytopenia ... DIC, TTP, HELLP, HUS ... #workup #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... life-threatening • Treatment ... #comparison #table ... #rheumatology # ... diagnosis #management
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
(HIT) - Diagnosis ... Diagnosis: • ... Confirmatory test ↑Se ... Management: • D/c all ... #Treatment #Hematology