34 results
Diuretic Electrolyte Excretion Effects 
Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid
 - Thiazide Type
Diuretic Electrolyte ... Excretion Effects Diuresis ... +, Mg2+, Ca2+, Cl ... electrolytes #effects #pharmacology ... #comparison #table
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
Myeloid Leukemia (AML ... drugs • ACE ... Cyclosporine • Diuretics ... Diagnosis #Algorithm #endocrinology ... #causes
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... • Inhibit Na+ Cl ... #Pharmacology # ... loop #thiazide #classes
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... Inhibitors of Na+K+2Cl ... Kidney stones caused ... #Nephrology #Pharmacology ... #Medications #Table
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
Hydroxyurea - Pathophysiology ... number of pain crises ... vs. 1) • Fewer ACS ... Benefits #SickleCell #pathophysiology ... #pharmacology
Management of Hyponatremia
Hypertonic Saline - Only indicated if patient has severe symptoms + Na < 125
Give
Failure - Add Diuretics ... Add Diuretics, Consider ... • Discuss with endocrinology ... SIADH — look for cause ... hourly • Identify Cause
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
organic acids and bases ... acid and most diuretics ... Segments #Function #Pathophysiology ... #Tubules #Table ... #Pharmacology
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... Januvia) - Once/day tablet ... not definitively cause ... DPP4 #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors - Pharmacology ... leading to osmotic diuresis ... heart disease • All ... SGLT2 #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Diagnosis Algorithm Cause ... intoxication Cause ... RENAL LOSS: - Diuresis ... ⁻ increase may cause ... Diagnosis #Algorithm #Pathophysiology