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Amphotericin B - Pharmacology Summary Sheet

Class: Polyene Antifungal
Mechanism of Action:
 • Binds to ergosterol → Complexes
Amphotericin B - ... Formulations: Amphotericin ... Lipid Complex), Ambisome ... #AmphotericinB ... #Pharmacology #ambisome
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview

Mechanism: binds ergosterol in membrane and
Antifungal Polyenes - Amphoterecin ... B, Abelcet, Ambisome ... Polyenes #Antifungal #AmphoterecinB ... #Abelcet #Ambisome
IDSA Recommendations for Treating Visceral and Cutaneous Leishmaniasis in HIV-AIDS
Treating Visceral Leishmaniasis - Preferred Therapy:
 •
• Liposomal amphotericin ... • Liposomal amphotericin ... • Liposomal amphotericin ... 4 weeks or • Amphotericin ... • Liposomal amphotericin
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
aminoglycosides, amphotericin ... , pentamidine, amphotericin
Antifungal Coverage Activity Antibiogram 

Spectrum of action of systemic antifungal agents. Solid blocks represent species in
AMB = amphotericin
Antifungal Agents Frequently Used in Leukemia
Antibiogram:
 • Fluconazole
 • Itraconazole
 • Voriconazole
 • Posaconazole
 • Caspofungin
Anidulafungin • Amphotericin
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
aminoglycosides, amphotericin
Classification of Some Antimicrobial Agents by Their Sites of Action
Inhibitors of metabolism: Sulfonamides, Trimethoprim
Inhibitors of cell
function: Isoniazid, Amphotericin
Hypokalemia - Differential Diagnosis
Poor Intake 
 - Starvation
 - Anorexia
GI Losses 
 - Vomiting / NG
nephropathy - Amphotericin
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
hyperbilirubinemia, liposomal amphotericin