63 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Evaluate an Abnormal APTT ... or APTT Artifactually ... Is a Systemic Disease ... or APTT? ... ISNeducation #Abnormal #APTT
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Prothrombin Time (PT ... Thromboplastin Time (PTT ... inhibitor • Liver disease ... Thromboplastin Time (PTT ... #PTT #Prothrombin
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal • ... Differential #Diagnosis #Management
Fantastic handout on anticoagulation by Dr. Jessie Donato, superstar medical educator and hospitalist at ⁦@ClevelandClinic⁩ ⁦@CCF_IMCHIEFS⁩

#Anticoagulation
#HeparinDrip #gtt ... #Algorithm #PTT ... #Monitoring #Management
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
and/or aPTT Prolonged ... Early liver disease ... typically prolong aPTT ... may prolong the aPTT ... and aPTT 1.
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
/PTT • Low plasma ... /INR: ↑ • PTT: ... • Severe Liver Disease ... INR < 2.3 - APTT ... causes #treatment #management
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... screening for disease ... with established disease ... ) • aPTT is prolonged ... mixing study (aPTT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... /ABNORMAL PTT: ... and the PTT suggests
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... 2B) • Normal PT ... INR • Normal aPTT ... VonWillebrand #Disease
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Diagnosis and Management ... Activation: Liver disease ... , Kidney Disease ... Hypocalcemia #Diagnosis #Management ... #endocrinology