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diagnosis rheumatology treatment coagulation workup algorithm dic disease disseminated druginduced intravascular lupus abnormal activation anticoagulation causes comparison differential dil doac
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
- Prolonged aPTT ... and Prolonged PT ... - Prolonged aPTT ... Coagulation #Abnormal #APTT ... #Laboratory #Hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Thromboplastin Time (PTT ... Thromboplastin Time (PTT ... #PTT #Prothrombin ... Thromboplastin #laboratory ... #hematology #diagnosis
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... /aPTT MAHA likely ... /aPTT normal • ... Differential #Diagnosis #Management ... #Algorithm #hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
GI. uterine) Laboratory ... 2B) • Normal PT ... INR • Normal aPTT ... Disease #Diagnosis #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/PTT • Low plasma ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... causes #treatment #management ... #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
PT and/or aPTT) ... Study #diagnosis #hematology ... pathophysiology #hematology ... #laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... Scoring #diagnosis #hematology ... #laboratory
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... Chronic Management ... #treatment #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... be performed PT ... , PTT, and fibrinogen ... Diagnosis #Workup #Hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
clotting time; TT ... anticoagulation #hematology ... #laboratory #testing ... #aptt
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