10 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Defects • G6PD ... Intravascular - Hemolysis ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Enzyme Defects: G6PD ... Urobilinogen #Hemolysis ... Differential #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Extravascular Hemolysis ... G6PD deficiency) ... differential #diagnosis #hematology
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Indications and Pharmacology ... Post-partum, ICH/TBI, Hemoptysis ... #Indications #Pharmacology ... #hematology
Medications to Avoid in Patients with G6PD Deficiency Due to Risk of Hemolysis
 - Chloroquine (Aralen)*
Patients with G6PD ... Due to Risk of Hemolysis ... Synthetase #G6PD ... Differential #Diagnosis #Pharmacology ... #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Retroperitoneal, Uterine • Hemolysis ... sickle cell anemia, G6PD ... Production #Index #hematology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
with caution] and G6PD ... limited) risk of hemolysis ... Benefits #Lupus #pharmacology ... #sideeffects #rheumatology
Drug-induced Hemolysis in G6PD Deficiency
Medicines and other substances likely to be UNSAFE in moderate to severe
Drug-induced Hemolysis ... in G6PD Deficiency ... moderate to severe G6PD ... #DrugInduced #Hemolysis ... #Pharmacology #
Nitrofurantoin Toxicology
Serious Adverse Effects:
Hemolysis in patients with G6PD-deficiency
Peripheral neuropathy
Hepatitis
Pulmonary toxicity
Nephritis

By Dr. Kathryn Watson @Kat_Watson

#Nitrofurantoin #Macrobid #Toxicity
Adverse Effects: Hemolysis ... patients with G6PD-deficiency ... Toxicity #Toxicology #Pharmacology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
edema, myopathy Hematologic ... marrow suppression, Hemolysis ... Toxicology #Phases #Pharmacology