16 results
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential ... • B12/Folate ... DeficiencyAplastic ... #Classification ... Algorithm #Causes #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Pancytopenia - Differential ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... Nutritional deficiency ... : • B12/folate
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... Non-hemolytic: ACD, Aplastic ... Spherocytosis, G6PD, PK, HbC ... , B12 deficiency ... #Diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Megakaryopoiesis • B12 ... Deficiency • ... Algorithm #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... (>100 fL) • B12 ... #MCV #Classification ... #Differential # ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Volume (MCV) - Differential ... • Marrow Aplasia ... • Early Iron Deficiency ... #Differential # ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... to repair DNA, as ... , GATA2 deficiency ... #hematology #diagnosis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
loss), Vitamin B12 ... marrow failure: Aplastic ... , G6PD deficiency ... Production #Index #hematology ... #anemia #differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
: Pyridoxine deficiency ... : Vitamin B12 or ... Folate deficiency ... #Morphology #differential ... #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... Neutrophils - Low RBC ... • Dietary Deficiency ... and Folate Deficiency ... Algorithm #Causes #Hematology