23 results
Wernicke Encephalopathy - Acute Thiamine (B1) Deficiency 
Clinical Diagnosis - Caine Criteria (2 out of 4):
Encephalopathy - Acute ... Thiamine (B1) Deficiency ... Clinical Diagnosis ... dysfunction and gait ... #criteria #neurology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential ... Blood Loss • Acute ... • B12/Folate ... Deficiency • Aplastic ... Diagnosis #Algorithm #Causes
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
kidney disease, Acute ... Megaloblastic: Vitamin B12 ... deficiency • ... morphologic #mcv #differential ... #diagnosis #causes
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... , or folate deficiency ... RBC turnover • Acute ... • Hemolytic anemia ... Diagnosis #DM2 #Differential
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... - AKI Workup Algorithm ... osmolarity If cause ... investigations depending on clinical ... #causes
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
Simplified Approach to Acute ... e.g AEIOU ) or anuria ... creatinine (in 12 ... CONSIDER INTRINSIC CAUSES ... KidneyInjury #simplified #workup
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... parasthesias, gait ... #Cobalamin #Deficiency
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
Nutritional: DiabetesB12 deficiency ... Fabry's disease, Acute ... Peripheral #Neuropathy #differential ... #diagnosis #causes ... #neurology
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... Crohn's > UC Anemia ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... /other causes
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
1) Clinical ... Whipple, vitamin deficiency ... Alzheimer - 1st cause ... - Progressive amnesia ... MNCD #Dementia #Differential