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diagnosis management algorithm causes rheumatology oncology syndrome classification infectiousdiseases chronic nephrology signs symptoms cll disorders erythematosus hemeonc leukemia lupus lymphocytic
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Inflammation, Chronic Infection ... (>100 fL) • B12 ... Classification #Differential ... Algorithm #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Myelofibrosis Infectious ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Macroangiopathic, Infections ... Folate deficiency, B12 ... Non-megaloblastic: Liver disease ... #Diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... consumption • Vitamin B12 ... deficiency Infections ... #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Thrombocytosis #Platelets #Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
loss), Vitamin B12 ... Chronic kidney disease ... (e.g. cancer, infection ... Production #Index #hematology ... #anemia #differential
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Malignancy Infectious ... Obstructive Pulmonary Disease ... Neurologic •
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Clinical Presentation ... • Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... #hematology #diagnosis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... fraction < 20% Differential ... Diaqnoses: • Infectious ... diagnosis #management #treatment ... #rheumatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... • Autoimmune diseases ... article/S0002-9343(12 ... #differential # ... neutrophil #WBC #CBC #hematology
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