47 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... months without treatment ... underlying liver disease ... Coagulation Failure Infections ... #Hepatology #gastroenterology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... : Chronic infections ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Myelofibrosis Infectious ... : • Acute or Chronic ... disorders • Celiac disease ... effect following treatment ... Algorithm #Causes #Hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
translocation • Acute ... thrombocythemia • Acute ... Colitis and Crohn’s Disease ... Irradiation • Cirrhosis ... Diagnosis #causes #hematology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
• HIV/HCV co-infection ... or fibrosis • Cirrhosis ... HBV infection with ... > 3 mg/dL) or acute ... Indications #management #hepatology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
>10 mmHg - clinically ... /acute hepatitis ... • Infiltrative diseases ... Veno-occlusive disease ... Diagnosis #causes #hepatology
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
Adjuvant therapies in critical ... diseases - Severe ... ventilation, ARDS acute ... #Pharmacology # ... Management #Treatment
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Liver disease ... - Cirrhosis ... fibrosis - Acute ... SAAG < 1.1 g/dL) Infections ... #differential #hepatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
loss), Vitamin B12 ... Chronic kidney disease ... (e.g. cancer, infection ... Index > 3: • Acute ... Production #Index #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... age, however the disease ... presents as an acute ... : • Infection ... #hematology