84 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
distinction has HUGE treatment ... and first-line treatment ... Microangiopathy #thrombocytopenic ... Comparison #Diagnosis #Table ... #Hematology
Venous Thromboembolism Treatment Algorithm
Branch points: 
Active bleeding?  Active malignancy? Provoked?

- Dr. Joseph Shatzel
@Clotmaster

#Management #VTE #DVT
Thromboembolism Treatment ... Thromboembolism #Treatment ... #Hematology #Anticoagulation
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
disorders • Celiac disease ... Non malignant hematologic ... effect following treatment ... following EtOH induced thrombocytopenia ... Algorithm #Causes #Hematology
Recurrent / Breakthrough DVT During Anticoagulation

Subtherapeutic Anticoagulation
Hypercoagulable State 
 - Antithrombin deficiency 
 - Hypercoagulability ot
Breakthrough DVT During Anticoagulation ... Subtherapeutic Anticoagulation ... - Behcet's disease ... Recurrent #DVT #VTE #anticoagulation ... #hematology #differential
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Diagnosis Algorithm Thrombocytopenia ... ASA) • Renal Disease ... Von Willebrand's Disease ... - Acquired • Anticoagulation ... Algorithm #Causes #Hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Treatment of Thrombotic ... Thrombocytopenic ... TTP Thrombotic #Thrombocytopenic ... #rheumatology # ... hematology
Algorithm for the Long-Term Treatment of Venous Thromboembolism 

Reference: https://doi.org/10.1182/blood.2019002364

by Dr. Clive Kearon and Dr. Susan
the Long-Term Treatment ... #LongTerm #Treatment ... Thromboembolism #VTE #Anticoagulation ... #Algorithm #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... platelet count (mild thrombocytopenia ... factor VIII) Treatment ... VonWillebrand #Disease ... #Diagnosis #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • B12 ... Heart Valve) #Thrombocytopenia ... Algorithm #Causes #Hematology
4T Score for Heparin-Induced Thrombocytopenia

Interpretation of the 4T score:
0-3 points:  Low probability (<<1%)
  -
Heparin-Induced Thrombocytopenia ... Consider therapeutic anticoagulation ... Initiate therapeutic anticoagulation ... HeparinInduced #Thrombocytopenia ... Diagnosis #Criteria #Hematology