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Treatments for Sickle Cell disease

#Sicklecell #sicklecelldisease #sicklecellanemia, #sicklecells #sickle #hematology #anemia #clinical #pediatrics #FOAM #FOAMed
Treatments for Sickle ... Cell disease ... #Sicklecell #sicklecelldisease ... #sickle #hematology ... #anemia #clinical
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Supportive with treatment ... hepatomegaly and anemia ... BrighamChiefs #SickleCell ... #hepatology #hepatitis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
- Low Serum B12 ... • Pancreatic Disease ... Myelodysplastic Syndromes ... • Liver Disease ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
chronic kidney disease ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... only curative treatment ... Myelodysplastic #Syndrome ... #hematology #oncology
Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
 • Congestive heart failure
 • Constrictive
- Oncotic • Cirrhosis ... Collagen vascular disease ... Gastrointestinal disease ... • Asbestos • Uremia ... Diagnosis #Algorithm #Hepatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework
LOW RETIC INDEX - ↓ PRODUCTION
 • Vitamin
in Cirrhosis - ... PRODUCTION • Vitamin B12 ... Peptic ulcer disease ... Destruction: Zieve's syndrome ... #Diagnosis #Hepatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... - Parvovirus B19 ... • Parvovirus B19 ... Treatment: ... #oncology #hematology