22 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Wiskott-Aldrich syndrome ... telomeropathy Cancer ... Antibody-mediated hemolysis ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Diagnosis #Algorithm #hematology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
LC deposition disease ... Minimal change disease ... • Hematologic ... malignancies Treatment ... #Oncology #Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
loss), Vitamin B12 ... Chronic kidney disease ... infiltration (e.g. cancer ... Microangiopathic hemolytic ... Production #Index #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... thrombocythemia), Autoimmune disease ... adsorption onto cancer ... Diagnosis #Management #treatment ... #hematology #differential
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Lymphoma or other cancers ... gastric and breast cancer ... and autoimmune hemolytic ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework
LOW RETIC INDEX - ↓ PRODUCTION
 • Vitamin
PRODUCTION • Vitamin B12 ... Peptic ulcer disease ... Destruction: Zieve's syndrome ... anemia, Hemolysis ... Differential #Diagnosis #Hepatology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... , breast CA - Hematologic ... cancer such as ... Treatment: - Systemic ... #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... cells can indicate disease ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Irritable Bowel Syndrome (IBS) - Diagnosis and Workup Summary
Use a positive diagnostic strategy with minimal testing.
Irritable Bowel Syndrome ... Diagnosis and Workup ... red flags - Low chance ... Gastroenterology and Hepatology ... #Diagnosis #workup