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hematology differential algorithm disease management oncology thrombocytosis anemia aplastic causes coagulation cobalamin defects deficiencies disorders hemolyticuremicsyndrome hus ileal inherited laboratory
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Hemophilia A - Deficiency ... Malabsorption (e.g. celiac ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
Disease - Diagnosis ... disease • Iron-deficiency ... unresponsive to treatment ... #Disease #Diagnosis ... #Algorithm #gastroenterology
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
Commonly Used Diagnostic ... negative with IgA deficiency ... Reflects response to treatment ... Laboratory #Tests #Diagnosis ... #Workup #Table
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... disorders • Celiac ... effect following treatment ... malignancy • Iron deficiency ... Algorithm #Causes #Hematology
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
distinction has HUGE treatment ... and first-line treatment ... thrombocytopenia #Comparison ... #Diagnosis #Table ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Acute hemolysis, deficiency ... Rebound effect from treatment ... Vasculitides, IBD, Celiac ... #Differential #Diagnosis
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... related to IBD, celiac ... Check for IF ab Treatment ... #Cobalamin #Deficiency ... #diagnosis #management
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
: 33% • Treatment ... : No • Treatment ... Transfusion #Reactions #hematology ... #diagnosis #comparison ... #table
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
a storage pool deficiency ... Platelet #Defects #comparison ... #table #differential ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
anemia, GATA2 deficiency ... , CTLA4 deficiency ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
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