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diagnosis differential rheumatology causes management lupus oncology sle symptoms systemic acidosis activation aplastic approach autoantibodies behcet cancer chronic cll dermatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Systemic lupus erythematosus ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... (>100 fL) • B12 ... #MCV #Classification ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... Deficiency • B12 ... #Classification ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... - Low Serum B12 ... Myelodysplastic Syndromes ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
- THE ALGORITHMIC ... staphylococcal scalded skin syndrome ... and toxic shock syndrome ... #Diagnosis #Dermatology ... Rash #Algorithm
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... Differential #Diagnosis #Algorithm
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Demyelinating syndromes ... ) Blood (75%): Anemia ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Neurological 12% ... - Hemolytic anemia ... autoantibodies #signs ... #differential #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... - Parvovirus B19 ... • Parvovirus B19 ... Treatment: ... #oncology #hematology
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